Apio Flow – 100% Celery Stalk Juice 500 ml

What Science Says About Celery

1. Blood pressure

A 2025 meta-analysis pooled nine randomised trials (ten intervention arms, 511 adults) of celery preparations — mostly seed extracts, seed powder, leaf powder or decoctions. Systolic and diastolic blood pressure were lower than in control groups (standardised mean differences −1.0 and −0.93). The clearest effect came from seed preparations and doses above 1,000 mg a day; the trials were small, all conducted in Asia and highly heterogeneous, and none used celery juice. [1]

The best single trial: 52 adults with hypertension took 1.34 g of celery seed extract daily for four weeks in a triple-blind, placebo-controlled crossover design. Twenty-four-hour ambulatory systolic pressure fell from 141.2 to 130.0 mmHg and diastolic from 92.2 to 84.2 mmHg, with no meaningful change on placebo. [2]

2. Fasting glucose and triglycerides

The same meta-analysis found lower fasting glucose (six trials) and lower triglycerides (three trials); total, LDL and HDL cholesterol did not change significantly. [1] In the crossover trial above, fasting glucose fell from 108.53 to 97.96 mg/dL on the seed extract. [3]

3. Uric acid

In a randomised, double-blind, placebo-controlled trial in 28 adults with metabolic syndrome, 150 mg a day of a celery seed extract standardised to 3-n-butylphthalide for twelve weeks lowered uric acid from 297.4 to 261.7 µmol/L and systolic pressure from 121.0 to 115.7 mmHg compared with placebo. Insulin sensitivity did not change. [4]

4. Phthalides — the compounds behind the aroma

Of the twelve most potent odorants identified in raw celery leaves and stalks, the phthalides — 3-n-butylphthalide, sedanenolide and the trans- and cis-sedanolides — were the most important to its character. [5] 3-n-butylphthalide is the compound behind a stroke medicine approved in China in 2002, and it is the molecule the uric-acid trial above standardised its extract to. [6] [4]

5. Dietary nitrate

In EU monitoring data covering 387 samples, celery carried a median of 693 mg of nitrate per kilogram fresh weight, with a mean of 1,103 mg/kg and a 95th percentile of 3,319 mg/kg. [7] Leaves hold roughly twice as much nitrate as stalks. [8]

6. Apigenin — an interesting molecule with thin human evidence

Celery contains the flavone apigenin, but where it sits matters: the USDA flavonoid database lists 78.65 mg of apigenin per 100 g for dried celery seed, a spice, not the fresh stalk, and the leaves carry more phenolic compounds than the stalks. [9] [8] Apigenin is widely discussed in connection with sleep, but a 2024 review notes that the human trials behind those claims used chamomile extract rather than apigenin on its own, and that clinical studies of apigenin alone are still needed. [10]

What has not been studied

No controlled trial has tested celery stalk juice. The one published report on the juice itself describes a single 74-year-old man whose blood pressure fell over six months of daily celery juice while he was also receiving other care; the author notes that one case cannot establish cause and effect. [11] The findings above come from concentrated seed and leaf preparations and describe the plant, not a promise about the juice.

Allergy and sensitivity

Celery is one of the fourteen allergens that must be declared on food labels in the EU. [12] Severe reactions occur mainly in people sensitised to mugwort pollen; in a 2024 study, sensitisation to the celery protein Api g 7 was linked to a markedly higher risk of anaphylaxis. [13] Celery also contains furanocoumarins, compounds that can make skin more sensitive to sunlight; levels in fresh stalks are low but rise several-fold during long storage and fungal infection. [14]

References

1. Liu D, Zhao H, Xu H, Hu J. Effects of celery (Apium graveolens) on blood pressure, glycemic and lipid profile in adults: a systematic review and meta-analysis of randomized controlled trials. Front Nutr. 2025;12:1597680. doi:10.3389/fnut.2025.1597680
2. Shayani Rad M, Moohebati M, Mohajeri SA. Effect of celery (Apium graveolens) seed extract on hypertension: a randomized, triple-blind, placebo-controlled, cross-over, clinical trial. Phytother Res. 2022;36(7):2889–2907. doi:10.1002/ptr.7469 · PMID 35624525
3. Shayani Rad M, et al. Safety evaluation and biochemical efficacy of celery seed extract (Apium graveolens) capsules in hypertensive patients: a randomized, triple-blind, placebo-controlled, cross-over, clinical trial. Inflammopharmacology. 2022;30(5):1669–1684. doi:10.1007/s10787-022-00986-0
4. Pérez-Rubio KG, Escobedo-Gutiérrez MJ, Cortez-Navarrete M, Martínez-Abundis E. Effect of celery seed (Apium graveolens L.) administration on the components of metabolic syndrome, insulin sensitivity, and insulin secretion: a clinical trial. Pharmaceuticals. 2026;19(1):110. doi:10.3390/ph19010110
5. Kurobayashi Y, Kouno E, Fujita A, Morimitsu Y, Kubota K. Potent odorants characterize the aroma quality of leaves and stalks in raw and boiled celery. Biosci Biotechnol Biochem. 2006;70(4):958–965. doi:10.1271/bbb.70.958
6. Wang Y, Shen Y, Liu Z, et al. Dl-NBP (dl-3-n-butylphthalide) treatment promotes neurological functional recovery accompanied by the upregulation of white matter integrity and HIF-1α/VEGF/Notch/Dll4 expression. Front Pharmacol. 2020;10:1595. doi:10.3389/fphar.2019.01595
7. EFSA Panel on Contaminants in the Food Chain (CONTAM). Nitrate in vegetables — scientific opinion of the Panel on Contaminants in the Food Chain. EFSA J. 2008;689:1–79.
8. Golubkina N, et al. Yield, growth, quality, biochemical characteristics and elemental composition of plant parts of celery leafy, stalk and root types grown in the Northern Hemisphere. Plants. 2020;9(4):484. doi:10.3390/plants9040484
9. US Department of Agriculture, Agricultural Research Service. USDA Database for the Flavonoid Content of Selected Foods, Release 3.3. 2018.
10. Kramer DJ, Johnson AA. Apigenin: a natural molecule at the intersection of sleep and aging. Front Nutr. 2024;11:1359176. doi:10.3389/fnut.2024.1359176
11. Illes JD. Blood pressure change after celery juice ingestion in a hypertensive elderly male. J Chiropr Med. 2021;20(2):90–94. doi:10.1016/j.jcm.2021.04.001
12. Regulation (EU) No 1169/2011 on the provision of food information to consumers, Annex II: substances or products causing allergies or intolerances.
13. Ballmer-Weber BK, Wangorsch A, Bures P, et al. New light on an old syndrome: role of Api g 7 in mugwort pollen–related celery allergy. J Allergy Clin Immunol. 2024;154:679–689.e5.
14. Aharoni N, Afek U, Finkelstein E, et al. Impact of celery age and infection by Botrytis cinerea on linear furanocoumarin (psoralens) content in stored celery. Phytoparasitica. 1996;24:195–197. doi:10.1007/BF02981418